Pyridoxamine

Pyridoxamine Pyridoxamine is a multifunctional product: targeting pathogenic glycation and oxidative damage.

Now that is one big headline. But basically it means that the impact that just living on this planet and breathing the air can have on your body is be extreme. The discovery that pyridoxamine (commonly referred to as PM) can inhibit glycation reactions couple with the advanced glycation end products (AGEs) that have been created gave a new impetus to this B6 vitamin as a prospective pharmacological agent for treatment of complications of diabetes.

Below are a few pieces of relevant information on pyridoxamine:

The mechanism of action of pyridoxamine includes:

(i) Inhibition of AGE formation by blocking oxidative degradation of the Amadori intermediate of the Maillard reaction;

(ii) Scavenging of toxic carbonyl products of glucose and lipid degradation; and

(iii) Trapping of reactive oxygen species.

The combination of these activities along with PM safety posture it as a promising drug candidate for treatment of diabetic complications as well as other multi-factorial chronic conditions in which oxidative reactions and carbonyl compounds confer pathogenicity.