Centrophenoxine

Centrophenoxine is considered both a nootropic and an anti-aging treatment. It has been shown to increase the life span of animals and protect the brain and skin from certain signs of aging. Centrophenoxine can also increase the use of glucose in the brain and improve brain energy while enhancing speed of memory recall. Cell oxygen consumption and carbon dioxide production also increase significantly when centrophenoxine is taken regularly. As a result, it has been found to be very effective in the treatment of various disorders such as brain damage due to old age or stroke and brain injury caused by chemicals or drugs (including excessive consumption of alcohol). Centrophenoxine can also protect against the damage caused by toxic chemicals in the environment.

The crucial characteristic of Centrophenoxine is in its ability to reduce levels of lipofuscin in cells. Both human and animal studies have shown that low levels of lipofuscin correlate with healthy cellular function, while high levels of lipofuscin accompany poor cellular health.

In experiments, one group of aging animals with high lipofuscin levels received centrophenoxine while a control group did not. The results of these experiments proved that memory and the ability to learn and remember (generally seen only in young animals) were restored in the treated group. There was no improvement in these abilities in the untreated group.

It is not clear exactly how Centrophenoxine works although it is known to remove a potassium build up, called lipofuscin, in the brain, heart, lungs and skin. Spots on the skin caused in this way are commonly known as liver spots or age spots. Lipofuscin has been linked to the Membrane Hypothesis of Aging. It is known that patients with Alzheimer's disease have much higher levels of lipofuscin than their healthy counterparts.

To communicate efficiently, through the transfer of potassium and sodium across its membranes, a cell must remain lipid and lipofuscin can inhibit this function. Centrophenoxine may help to slow down and repair some of this loss of membrane function and, for this reason, has become a recognized and important anti-aging medicine.

Centrophenoxine has also been shown to increase production of brain RNA (ribonucleic acid) and protein; and to encourage an increase in glucose uptake. Improved energy production means that the patient's oxygen consumption and carbon dioxide production increase significantly. Although it is not fully explained, part of centrophenoxine breaks down into DMAE (dimethylaminoethanol), which stays in the brain membranes and nerve cells for long periods and acts as a free radical scavenger. The presence of DMAE in the brain cell membrane provides increased protection against damaging free radical attacks, and may also act as a precursor to acetylcholine, the neurotransmitter.

Centrophenoxine should not be taken by patients with very high blood pressure or convulsive disorders (such as epilepsy) or by pregnant or lactating women.

Centrophenoxine may be synergistic with other nootropic drugs, so the combined dose overall should be lowered where these are being used concurrently.

Centrophenoxine, in normal therapeutic doses, is almost devoid of side effects. Some patients may experience headaches, nausea, or mild dizziness. In case of intoxication, the manufacturer recommends prescribing sedatives.

Centrophenoxine (taken over long periods or in high doses) may raise levels of acetylcholine significantly and lead to muscle stiffness. If this occurs, reducing the dose (or stopping it altogether) will alleviate the problem. Occasional breaks in treatment are advised. The appearance of muscle aches and pains may be a sign of overdose and mean that intake should be reduced.

DOSAGE

Doses are 250mg or 500mg, once or twice a day.